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KMID : 1098420060140040206
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Korean Journal of Medicinal Crop Science
2006 Volume.14 No. 4 p.206 ~ p.211
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Effect of Aqueous Extracts from Rubus coreanus Miquel and Angelica gigas Nakai on Anti-tumor and Anti-stress activities in mice
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Kim Jung-Hwa
Kim Cheol-Hee
Kim Hyo-Sung
Kwon Min-Cheol
Song Young-Kyu
Seong Nak-Sul
Lee Seung-Eun
Yi Jae-Seon
Kwon Oh-Woung
Lee Hyeon-Yong
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Abstract
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This study was performed to examine antitumor activities of Rubus coreanus Miquel and Angelica gigas Nakai extracts against sarcoma-180 and anti-stress activities in ICR mice. The variation of body weights of the 20 days of Rubus coreanus extracts-administrated mice group was very low. The survival rate (T/C %) of Rubus coreanus extract administrated group was 161% after 50 days from the inoculation of sarcoma-180 and the increment of their body weights was suppressed. Anti-stress effect of the extracts of R. coreanus and A. gigas were estimated by maeasuring blood chemical value and internal organs weight in ICR mice. The extracts of R. coreanus reduced the cholesterol and glucose to the normal level in the all stress animal models. The extracts of R. coreanus reduced the hypertrophy of the internal organs such as adrenal, spleen and liver to the regular level.
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KEYWORD
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Rubus coreanus Miquel, Angelica gigas Nakai, Sarcoma-180, antitumor activity, anti-stress activity, mice
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